So, UR4 has now been released which addresses a number of issues, including the previously attempted fix for APM causing IIS crashes.
However, one of the main changes is the additional support for TLS 1.2 as SSL and early TLS are not considered strong cryptography. More details on this from Jarrett Renshaw here. You can find more specific information relating to TLS 1.2 here, which is also linked to in Jarrett’s blog. This guide explains the changes that are needed for the various System Center products in order to enable TLS 1.2.
You can obtain the UR4 update for SCOM here.